Diabetes and its related intricacies force huge impact on social insurance & health care network. The overwhelming inconveniences of diabetes are for macro and micro vascular disease. Micro vascular disease condition, including nephropathy, builds up a few years after the beginning of diabetes (Cade, 2008). Introduction of tissues to the high blood glucose condition called hyperglycemia, is the primary starting element of onset of diabetes neuropathy, although genetic makeup is also important in deciding the susceptibility to diabetic nephropathy. Diabetic nephropathy is the number one reason for the end-stage renal/kidney disease (ESRD) and is related to enhance cardiovascular mortality. The major symptoms of diabetic nephropathy are the continues presence of albumin in the urine along with diabetes type 1 and type 2 (Gariani et al., 2012). The cost of treatment and care for the diabetic patient is huge in the ESRD. World health organization Renal data system incontestable a dramatic increase within the incidence of ESRD due to diabetes (Wang and Sarah, 2006). More than 44% of new cases of ESRD has been reported for diabetes patient. 40% population has been reported for diabetes between 1984-1996, but the population started treatment for ESRD has been increased to 400 times. Diabetic nephropathy occurrence in population grew to 37% between 1996-2005 and is expected to increase in further years. Afkarian et al. (2016) reported that every 4th diabetic patient in the United States of America is suffering from renal disease.